ال ceftazidime واحد من أدويه الجيل التالت لعيلة ال cephalospotin
اللي بيشتغل كويس ع gram negative وخاصة ع
Pseudomonas
طيب نشوف شو ال Indication اله وجرعاته بالأطفال ♀
1⃣General dosing, susceptible infection (IM, IV: Infants, Children, and Adolescents)
️ Non-Pseudomonas spp. infections:
90 to 150 mg/kg/day divided every 8 hours; maximum daily dose: 6 g/day.
️Pseudomonas spp. infections:
Mild to moderate infections: 90 to 150 mg/kg/day divided every 8 hours; maximum daily dose: 6 g/day.
Severe infections: 200 to 300 mg/kg/day divided every 8 hours; maximum daily dose: 12 g/day.
2⃣Cystic fibrosis, lung infection caused by Pseudomonas spp. or other susceptible gram negative organisms
Traditional intermittent infusion method:
Infants, Children, and Adolescents: IV: 200 to 400 mg/kg/day divided every 6 to 8 hours; maximum daily dose: 12 g/day
Continuous infusion method:
Children ≥5 years and Adolescents: IV: 100 to 200 mg/kg/day infused continuously over 24 hours; maximum daily dose: 12 g/day
لو كانت الحالة sepsis يُفضل اعطاء loading dose قبل ال
Continuous infusion
initial loading dose (60 mg/kg; maximum dose: 2,000 mg/dose) once before starting the continuous infusion
3⃣Endocarditis, treatment: Children and Adolescents:
IV: 100 to 150 mg/kg/day divided every 8 hours
(maximum daily dose: 4,000 mg/day)
use in combination with gentamicin or vancomycin and gentamicin (plus rifampin if prosthetic material is present) depending on the cause of infection.
4⃣Intra-abdominal infections, complicated: Infants, Children, and Adolescents: IV: 50 mg/kg/dose every 8 hours in combination with metronidazole; maximum daily dose: 6 g/day
5⃣Meningitis, including healthcare-associated ventriculitis/meningitis:
Infants, Children, and Adolescents:
IV: 150 to 200 mg/kg/day in divided doses every 8 hours; maximum daily dose: 6 g/day; use in combination with vancomycin for empiric coverage
6⃣Urinary tract infection: Infants, Children, and Adolescents:
IV: 100 to 150 mg/kg/day divided every 8 hours
لو كان الطفل عنده مشاكل بالكلى وال serum creatinine اعلى من الطبيعي بنعدل الجرعه حسب قيم ال GFR
Renally adjusted dose recommendations are based on a usual dose of 25 to 50 mg/kg/dose every 8 hours
1⃣GFR >50 mL/minute/1.73 m2: No adjustment required.
2⃣GFR 30 to 50 mL/minute/1.73 m2: 50 mg/kg/dose
every 12 hours.
3⃣GFR 10 to 29 mL/minute/1.73 m2: 50 mg/kg/dose every 24 hours.
4⃣GFR <10 mL/minute/1.73 m2: 50 mg/kg/dose every 48 hours.
5⃣Hemodialysis: Dialyzable (50% to 100%): 50 mg/kg/dose every 48 hours, give after dialysis on dialysis days.
6⃣Peritoneal dialysis: 50 mg/kg/dose every 48 hours.
7⃣Continuous renal replacement therapy (CRRT): 50 mg/kg/dose every 12 hours
