The most natural and common way to complete that sentence is:
"What's the matter? You look sad."
Other possibilities, depending on the context, could include:
- You seem sad.
- You are sad.
اذا كان لديك إجابة افضل او هناك خطأ في الإجابة علي سؤال What’s the matter? You ___ sad اترك تعليق فورآ.